Useful information from Power of Positivity on depression’s effects on the brain and treatment.
According to co-author Professor Ian Hickie:
“[The] more episodes of depression a person had, the greater the reduction in hippocampus size. So recurrent or persistent depression does more harm to the hippocampus the more you leave it untreated.
This largely settles the question of what comes first: the smaller hippocampus or the depression? The damage to the brain comes from recurrent illness…
Other studies have demonstrated reversibility, and the hippocampus is one of the unique areas of the brain that rapidly generates new connections between cells, and what are lost here are connections between cells rather than the cells themselves.